圣诞节日，这株肿瘤细胞你的圣诞袜里，有吗

冬季新品三部曲之“IO肿瘤免疫细胞株”

I wish you a merry Christmas. All affection and best wishes to you and yours.

Silent night！Holy night！

All is calm, all is bright！

Christmas Eve is the red heart in the snow armor,

 Cobioer will bring you IO tumor immune cell line.

新品简介

免疫检查点分子逐渐被认为是肿瘤免疫治疗的新靶标，它通常被肿瘤细胞“劫持”，以束缚免疫系统发挥有效的抗肿瘤反应的能力。免疫检查点阻断（Immune Checkpoint Blockade）是激活抗肿瘤免疫的有希望的方法。细胞毒性T淋巴细胞相关抗原4（CTLA-4）和程序性细胞死亡受体1（PD-1）是目前研究的透彻的免疫检查点分子，anti-CTLA4和anti-PD1单克隆药物已经在多种恶性肿瘤的临床试验中展现出不错的疗效。

案例展示

OX40 / CD134是肿瘤坏死因子（TNF）受体家族的成员。它是一种有效的共刺激途径的一部分，当被触发时可以在几种临床前癌症模型以及人类中增强T细胞记忆，增殖和抗肿瘤活性，从而克服癌症的一些免疫抑制性质。

OX40 / CD134 is a member of the tumor necrosis factor (TNF) receptor family. It is part of a potent co-stimulatory pathway that when triggered can enhance T-cell memory, proliferation and antitumor activity in several preclinical cancer models as well as in humans thus overcoming some of the immunosuppressive properties of cancer. 

Fig 1. FACS analysis of OX40 in HEK293 cells

OX40-HEK293 cells were stained with FITC-labeled anti-OX40 antibody and analyzed by FACS.

Y-axis shows the cell count. X-axis shows the intensity of FITC fluorescence.  

Fig 2. Dose Response of OX40 / NF-κB Reporter – HEK293 cells to OX40L. The results are shown as RLU signal of NF-κB luciferase reporter expression. The EC50 of OX40L is 6.5 ng/ml.

Fig 3. OX40/OX40L Immune Checkpoint Pathway

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