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药靶细胞株 > kinase激酶细胞株 > CBP73223EGFR H773_V774insPHPH/BaF3

EGFR H773_V774insPHPH/BaF3
名称 EGFR H773_V774insPHPH/BaF3
型号 CBP73223
报价
特点 EGFR H773_V774insPHPH/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO
  • 详细内容
CBP73223
I. Introduction

Cell Line Name:

EGFR H773_V774insPHPH/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

EGFR (HER1), epidermal growth factor receptor, is a tyrosine kinase receptor, which activates RAS/RAF/MEK and PI3K/AKT/mTOR pathways, leading to increased cell proliferation and growth (PMID: 24312144). EGFR activating mutations, amplification, and overexpression are found in a variety of tumors, including non-small cell lung cancer (PMID: 26609494, PMID: 30284706) and colorectal cancer (PMID: 30243897), and the EGFRvIII variant is commonly found in glioblastoma (PMID: 30201736).

III. Representative Data

1. WB of EGFR H773_V774insPHPH/BaF3

CBP73223-1.jpg

2. Anti-proliferation assay


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