加入收藏 | 设为首页 | 联系我们

产品搜索

相关文章

联系我们

联系人:蒋经理
电话:86-25-86880024
号码:86-25-86880024
手机:18066071954
地址:南京市雨花区长虹路222号
Email: zhangxiangwen@cobioer.com

产品展示 / PRODUCTS
药靶细胞株 > kinase激酶细胞株 > CBP73050EGFR L861Q/BaF3

EGFR L861Q/BaF3
名称 EGFR L861Q/BaF3
型号 CBP73050
报价
特点 EGFR L861Q/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO
  • 详细内容
CBP73050
I. Introduction

Cell Line Name:

EGFR L861Q/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative


II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.


III. Representative Data

1. WB of EGFR L861Q/BaF3

CBP73050-1.jpg

2. Anti-proliferation assay

CBP73050-2.jpg

Figure 2. Anti-proliferation assay of three reference compounds on the EGFR L861Q/BaF3 Stable Cell Line.



如果你对CBP73050EGFR L861Q/BaF3感兴趣,想了解更详细的产品信息,填写下表直接与厂家联系:


留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7

化工仪器网

推荐收藏该企业网站