名称 | EGFR V769_D770insGVV/BaF3 |
型号 | CBP73222 |
报价 | |
特点 | EGFR V769_D770insGVV/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO |
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药靶细胞株 > kinase激酶细胞株 > CBP73222EGFR V769_D770insGVV/BaF3
- 详细内容
CBP73222 | |
I. Introduction | |
Cell Line Name: | EGFR V769_D770insGVV/BaF3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
II.Background | |
EGFR V769_D770insGVV results in the insertion of three amino acids in the protein kinase domain of the Egfr protein between amino acids 769 and 770 (UniProt.org). V769_D770insGVV has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160). | |
III. Representative Data | |
1. WB of EGFR V769_D770insGVV/BaF3 | |
2. Anti-proliferation assay |