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药靶细胞株 > 免疫治疗细胞株 > CBP74124CD47+ Target Cell Line

CD47+ Target Cell Line
名称 CD47+ Target Cell Line
型号 CBP74124
报价
特点 CD47+ Target Cell Line,冻存条件:90% FBS+10% DMSO
  • 详细内容

 

CBP74124
I. Background
CD47 (also known as Rh-associated protein, GP42, integrin-associated protein (IAP), and neurophilin,) is an immunoglobulin-like protein that interacts with its receptor, Signal-regulatory protein alpha (SIRPα), on macrophages. This binding interaction regulates transmigration, oxidative burst cytokine production, and phagocytosis, creating a “don’t eat me” signal. CD47 is ubiquitously expressed on the surface of normal cells, but is overexpressed in numerous cancer cells, where it is thought to contribute to the resistance of tumors to phagocyte-dependent clearance.
 
II. Introduction
Expressed gene:CD47
Stability:32 passages
Synonym(s):Rh-associated protein, GP42, integrin-associated protein (IAP), and neurophilin
Freeze Medium:90% FBS+10% DMSO
Culture Medium: 
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
 
III. Representative Data

 

CBP74124.png

CBP74124-1.png



Figure 2. Dose response of Sirpɑ Blocking Antibodies in SIRPɑ Effector Reporter Cells With CD47+ Target Cells.


CBP74124-2.png


Figure 3. Dose response of CD47 Blocking Antibody in SIRPɑ Effector Reporter Cells(C11) With CD47+ Target Cells.

 

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