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药靶细胞株 > GPCR细胞株 > CBP71330CCR5/Ga16/CHO

CCR5/Ga16/CHO
名称 CCR5/Ga16/CHO
型号 CBP71330
报价
特点 CCR5/Ga16/CHO 冻存条件:90% FBS+10% DMSO,培养基:F12K+10%FBS+400ug/ml G418
  • 详细内容

 

CBP71330
I. Background

C-C chemokine receptor type 5 (CCR5) is a G protein-coupled receptor and a co-receptor for the entry of human
immunodeficiency virus-1 (HIV-1) into cells. CCR5 chemokine receptor is involved in leucocytes chemotaxis to sites of
inflammation and plays an important role in the macrophages, T cells, and monocytes recruitment. The chemokine
ligands that bind to CCR5 are regulated on activation, normal T Cell expressed and secreted (RANTES) and macrophage inflammatory protein 1 alpha (MIP1α). GenScript’s human CCR5-expressing stable subline is guaranteed to function properly in the calcium flux assay.

 
II. Introduction
Host Cell:

CHO-K1

Expressed gene:GenBank accession number NM_000579; no expressed tags
Stability:32 passages
Synonym(s):

C-C chemokine receptor type 5, CCR5

Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+400ug/ml G418
Mycoplasma Status:Negative
Storage:Liquid nitrogen immediately upon delivery
Application(s):

Functional assay for CCR5 receptor

Transducer:Gi
 
Ⅲ. Description of Host Cell Line
Organism:Hamster
Tissue:Ovary
Morphology: Epithelial-like
Growth Properties: Adherent
 
Ⅳ.Representative Data

Concentration-dependent stimulation of intracellular calcium mobilization by Rantes in CCR5/Ga16/CHO and CHO cells.

 

 

Figure 1. Rantes-induced concentration-dependent stimulation of intracellular calcium mobilization in CCR5/Ga16/CHO and CHO cells. The cells were loaded with Calcium-4prior to stimulation with an CCR5 receptor agonist, Rantes. The intracellular calcium change was measured by FlexStation.

 

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