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药靶细胞株 > GPCR细胞株 > CBP71331NPY2R/Ga16/HEK293

NPY2R/Ga16/HEK293
名称 NPY2R/Ga16/HEK293
型号 CBP71331
报价
特点 NPY2R/Ga16/HEK293 冻存条件:90% FBS+10% DMSO,培养基:F12K+10%FBS+400ug/ml G418
  • 详细内容
CBP71331
I. Background

The NPY family consists of three 36-amino acid peptides, neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP), which bind to the NPY receptors. At present five distinct NPY receptors, Y1, Y2, Y4, Y5, and y6, have been established by receptor cloning studies and all of them are Gi-coupled GPCRs. Activation of NPY receptors mediate a variety physiological effects including stimulation of food intake, inhibition of anxiety in the CNS, presynaptic inhibition of neurotransmitter release in the CNS and periphery, modulation of circadian rhythm, release of pituitary hormones, modulation of hippocampal activity, pain transmission, vasoconstriction, inhibition of insulin release and modulation of renal function. With regard to endogenous agonists, the receptors Y2 preferentially bind NPY and PYY.

 
II. Introduction
Host Cell:

HEK293

Stability:20 passages
Freeze Medium:90% FBS+10% DMSO
Culture Medium:DMEM+10%FBS+400ug/ml G418
Mycoplasma Status:Negative
Storage:Liquid nitrogen immediately upon delivery
Application(s):

Functional assay for NPY2 receptor

Transducer:Gi
 
Ⅲ. Description of Host Cell Line
Organism:Human
Tissue:kidney
Morphology: Epithelial
Growth Properties: Adherent
 
Ⅳ. Representative Data
 

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