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药靶细胞株 > 免疫治疗细胞株 > CBP74132Claudin18.2/ KATOIII 免疫治疗细胞株

Claudin18.2/ KATOIII 免疫治疗细胞株
名称 Claudin18.2/ KATOIII 免疫治疗细胞株
型号 CBP74132
报价
特点 Claudin18.2/ KATOIII
  • 详细内容


CBP74132
I. Background

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.


II. Introduction
Host Cell:

KATOIII

Expressed gene:

Claudin18.2

Stability:32 passages
Freeze Medium:90% FBS+10% DMSO
Culture Medium:


Mycoplasma Testing:Negative
Storage:Liquid nitrogen

III. Description of Host Cell Line
Species:Homo sapiens, human
Tissue:Stomach; derived from metastatic site: pleural effusion and supraclavicular and axillary lymph nodes and Douglas cul-de-sac
Disease: Gastric carcinoma
Morphology: Spherical
Growth Properties: mixed, adherent and suspension

IV. Representative Data

1. Claudin18.2/ KATOIII





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