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药靶细胞株 > kinase激酶细胞株 > CBP73336PDGFRA V658A/BaF3 kinase细胞株

PDGFRA V658A/BaF3 kinase细胞株
名称 PDGFRA V658A/BaF3 kinase细胞株
型号 CBP73336
报价
特点 PDGFRA V658A/BaF3
  • 详细内容


CBP73336
I. Introduction

Cell Line Name:

PDGFRA V658A/BaF3

Gene Synonyms:

PDGFRA

Host Cell:

Ba/F3

Stability:16 passages

Application:


Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

II.Background

PDGFRA, platelet-derived growth factor receptor alpha, is a receptor tyrosine kinase that activates PI3K/Akt, RAS/MAPK, and JAK/STAT pathways to promote cell proliferation and survival (PMID: 21605429). PDGFRA mutations have been detected in melanoma, AML, peripheral nerve sheath tumors, sarcoma, and neuroendocrine carcinomas (PMID: 23752188, PMID: 20685895), several fusions have also been reported (PMID: 22432087, PMID: 26276769), and amplification has been observed in glioblastoma (PMID: 23438035).

III. Representative Data

1.Sanger of PDGFRA V658A/BaF3

Figure 1. PDGFRA V658A/BaF3 V658A

2. Anti-proliferation assay

Figure 2. CTG Proliferation Assay of BaF3 PDGFRA V658A Cells (C3).




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