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药靶细胞株 > GPCR细胞株 > CBP71354CCR6/CHO

CCR6/CHO
名称 CCR6/CHO
型号 CBP71354
报价
特点 CCR6/CHO 冻存条件:90% FBS+10% DMSO
  • 详细内容
CBP71354
I. Background

CCR6 is a CC chemokine receptor that is selectively expressed in immature dendritic cells and memory T-cells. It primarily couples through Gi/o proteins upon activation. CCR6 plays an important role on skin and mucosal surfaces under homeostatic and inflammatory conditions, particularly through the recruitment of proinflammatory IL17-producing T-cells to sites of inflammation. Therefore, CCR6 is a potential target for several inflammatory and autoimmune diseases including psoriasis and inflammatory bowel disease. In human and mouse, CCR6 is exclusively activated by the chemokine CCL20, which is known to interact only with CCR6.


II. Introduction
Host Cell:

CHO

Stability:20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+5ug/ml puromycin
Mycoplasma Status:Negative
Storage:Liquid nitrogen immediately upon delivery
Application(s):

Functional assay for CCR6 receptor

Transducer:N/A

Ⅲ. Description of Host Cell Line
Organism:Hamster
Tissue:Ovary
Morphology: Epithelial
Growth Properties: Adherent

Ⅳ. Representative Data

Figure 2. CCL20 effect on CCR6/CHO-K1 clone 3.





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