| 名称 | CCR6/CHO |
| 型号 | CBP71354 |
| 报价 |  |
| 特点 | CCR6/CHO 冻存条件：90% FBS+10% DMSO |
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- 详细内容
| CBP71354 | |
| I. Background | |
CCR6 is a CC chemokine receptor that is selectively expressed in immature dendritic cells and memory T-cells. It primarily couples through Gi/o proteins upon activation. CCR6 plays an important role on skin and mucosal surfaces under homeostatic and inflammatory conditions, particularly through the recruitment of proinflammatory IL17-producing T-cells to sites of inflammation. Therefore, CCR6 is a potential target for several inflammatory and autoimmune diseases including psoriasis and inflammatory bowel disease. In human and mouse, CCR6 is exclusively activated by the chemokine CCL20, which is known to interact only with CCR6. | |
| II. Introduction | |
| Host Cell: | CHO |
| Stability: | 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5ug/ml puromycin |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): | Functional assay for CCR6 receptor |
| Transducer: | N/A |
| Ⅲ. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| Ⅳ. Representative Data | |
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Figure 2. CCL20 effect on CCR6/CHO-K1 clone 3. | |
