加入收藏 | 设为首页 | 联系我们

产品搜索

相关文章

联系我们

联系人:蒋经理
电话:86-25-86880024
号码:86-25-86880024
手机:18066071954
地址:南京市雨花区长虹路222号
Email: duhaitao@cobioer.com

产品展示 / PRODUCTS
药靶细胞株 > kinase激酶细胞株 > CBP73212EGFR DEL19-T790M-C797S/PC9 kinase细胞株

EGFR DEL19-T790M-C797S/PC9 kinase细胞株
名称 EGFR DEL19-T790M-C797S/PC9 kinase细胞株
型号 CBP73212
报价
特点 EGFR DEL19-T790M-C797S/PC9
  • 详细内容
CBP73212
I. Introduction

Cell Line Name:

EGFR DEL19-T790M-C797S/PC9

Host Cell:

PC9

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and Cell-based kinase assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
II.Background
EGFR is widely recognized for its importance in cancer. Amplification and mutations have been shown to be driving events in many cancer types. Its role in non-small cell lung cancer, glioblastoma and basal-like breast cancers has spurred many research and drug development efforts. Tyrosine kinase inhibitors have shown efficacy in EGFR amplfied tumors, most notably gefitinib and erlotinib. Mutations in EGFR have been shown to confer resistance to these drugs, particularly the variant T790M, which has been functionally characterized as a resistance marker for both of these drugs. The later generation TKI's have seen some success in treating these resistant cases, and targeted sequencing of the EGFR locus has become a common practice in treatment of non-small cell lung cancer. Overproduction of ligands is another possible mechanism of activation of EGFR. ERBB ligands include EGF, TGF-a, AREG, EPG, BTC, HB-EGF, EPR and NRG1-4 (for detailed information please refer to the respective ligand section). In ligand-activated cancers, Cetuximab appears to be more effective than tyrosine-kinase inhibitors.
 
III. Representative Data

1.WB of  EGFR DEL19-T790M-C797S/PC9 expression


2. Sanger of EGFR DEL19-T790M-C797S/PC9

Figure 1. EGFR DEL19-T790M-C797S/PC9 19del

Figure 2. EGFR DEL19-T790M-C797S/PC9 T790M

Figure 3. EGFR DEL19-T790M-C797S/PC9 C797S

 3.Anti-proliferation assay


Figure. Anti-proliferation assay of three reference compounds on theCCK8 Proliferation Assay of EGFR DEL19-T790M-C797S/PC9 cells Line.

如果你对CBP73212EGFR DEL19-T790M-C797S/PC9 kinase细胞株感兴趣,想了解更详细的产品信息,填写下表直接与厂家联系:


留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7
QQ在线客服
电话咨询
  • 25-86880024
  • 手机:18066071954

化工仪器网

推荐收藏该企业网站
扫一扫访问手机站扫一扫访问手机站
访问手机站