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基因检测标准品 > Mutation > CBP10519AI-Edigene® ABL1 p.T315I Reference Standard P

AI-Edigene® ABL1 p.T315I Reference Standard P
名称 AI-Edigene® ABL1 p.T315I Reference Standard P
型号 CBP10519
报价
特点 AI-Edigene® ABL1 p.T315I Reference Standard Plus
  • 详细内容
 CBP10519
FormatGenomic DNA
DescriptionABL1 T315I is a gatekeeper mutation that lies within the hinge region of the protein kinase domain of the Abl1 protein (PMID: 18794843). T315I has been demonstrated to occur as a secondary resistance mutation and results in increased kinase activity and transformation in the context of BCR-ABL1 in cell culture (PMID: 11423618, PMID: 18794843, PMID: 27890928), and results in reduced catalytic efficiency (kcat/km) in an in vitro assay (PMID: 30684523), but has not been fully characterized and therefore, its effect on Abl1 protein function is unknown.
  
Technical Data 
DNA Changec.944C>T
AA Changep.T315I
Mutation typeSubstitution - Missense
ZygosityHomozygous
Allelic Frequency100.00%
TranscriptNM_007313.2
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

10519.png

Storage4°C
Expiry36 months from the date of manufacture

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