Cell Line Name：

EGFR A763_Y764insFQEA/BaF3

Host Cell:

Ba/F3

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

Complete Culture Medium:

Mycoplasma Status:

Negative

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR A763_Y764insFQEA results in the insertion of four amino acids in the C-helix region of the Egfr protein between amino acids 763 and 764 (PMID: 24353160). A763_Y764insFQEA confers a gain of function to Egfr, as indicated by increased kinase activity and is transforming in cell culture (PMID: 24353160, PMID: 29533785).

1. WB of EGFR A763_Y764insFQEA/BaF3

2. Sanger of EGFR A763_Y764insFQEA/BaF3

3. Anti-proliferation assay

Figure 3. CTG Proliferation Assay of BaF3 EGFR A763_ Y764insFQEA (C21).