| 名称 | EGFR D770_N771insG/BaF3 |
| 型号 | CBP73178 |
| 报价 |  |
| 特点 | EGFR D770_N771insG/BaF3,母细胞：BaF3 EGFR 是 EGF 家族成员的受体，是一种具有酪氨酸激酶活性的跨膜糖蛋白。 D770_N771insG 尚未进行生化表征，但根据其他 Egfr 外显子 20 插入的影响，预计会导致功能增强。 |
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药靶细胞株 > kinase激酶细胞株 > CBP73178EGFR D770_N771insG/BaF3
- 详细内容
| CBP73178 | |
| I. Introduction | |
Cell Line Name： | EGFR D770_N771insG/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
Mycoplasma Status: | Negative |
| II.Background | |
EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity.EGFR D770_N771insG results in the insertion of a glycine (G) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insG has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions. | |
| III. Representative Data | |
1. WB of EGFR D770_N771insG/BaF3
| |
2. Anti-proliferation assay | |
