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药靶细胞株 > kinase激酶细胞株 > CBP73178EGFR D770_N771insG/BaF3

EGFR D770_N771insG/BaF3
名称 EGFR D770_N771insG/BaF3
型号 CBP73178
报价
特点 EGFR D770_N771insG/BaF3,母细胞:BaF3 EGFR 是 EGF 家族成员的受体,是一种具有酪氨酸激酶活性的跨膜糖蛋白。 D770_N771insG 尚未进行生化表征,但根据其他 Egfr 外显子 20 插入的影响,预计会导致功能增强。
  • 详细内容
CBP73178
I. Introduction

Cell Line Name:

EGFR D770_N771insG/BaF3

Gene Synonyms:

ERBB, mENA, ERBB1, HER1

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity.EGFR D770_N771insG results in the insertion of a glycine (G) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insG has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions.

III. Representative Data

1. WB of EGFR D770_N771insG/BaF3

CBP73178-1.jpg


2. Anti-proliferation assay


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