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药靶细胞株 > kinase激酶细胞株 > CBP73169EGFR G719S/BaF3

EGFR G719S/BaF3
名称 EGFR G719S/BaF3
型号 CBP73169
报价
特点 EGFR G719S/BaF3,母细胞:BaF3,培养基:1640+10%FBS+2ug/ml puromycin
  • 详细内容

  

CBP73169
I. Introduction

Cell Line Name:

EGFR G719S/BaF3

Gene Synonyms:

ERBB, mENA, ERBB1, HER1

Host Cell:

Ba/F3

Stability:16 passages

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.

 
III. Representative Data

1. Anti-proliferation assay

 

CBP73169 fig.jpg


Figure 1. Anti-proliferation assay of three reference compounds on the EGFR G719S/BaF3 Stable Cell Line.

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