EGFR H773_V774insAH/BaF3-南京科佰生物科技有限公司

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Email： zhangxiangwen@cobioer.com

名称	EGFR H773_V774insAH/BaF3
型号	CBP73220
报价
特点	EGFR H773_V774insAH/BaF3,母细胞：BaF3，冻存条件：90% FBS+10% DMSO

CBP73220
I. Introduction
Cell Line Name：	EGFR H773_V774insAH/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
EGFR H773_V774insAH results in the insertion of two amino acids within the drug-binding pocket in the protein kinase domain of the Egfr protein between amino acids 773 and 774 (UniProt.org, PMID: 23371856). H773_V774insAH has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertion mutations (PMID: 24353160).

III. Representative Data
1. WB of EGFR H773_V774insAH/BaF3