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药靶细胞株 > kinase激酶细胞株 > CBP73220EGFR H773_V774insAH/BaF3

EGFR H773_V774insAH/BaF3
名称 EGFR H773_V774insAH/BaF3
型号 CBP73220
报价
特点 EGFR H773_V774insAH/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO
  • 详细内容

 

CBP73220
I. Introduction

Cell Line Name:

EGFR H773_V774insAH/BaF3

Gene Synonyms:

ERBB, mENA, ERBB1, HER1 

Host Cell:

Ba/F3

Stability:16 passages

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

 

Mycoplasma Status:

Negative

 
II.Background

EGFR H773_V774insAH results in the insertion of two amino acids within the drug-binding pocket in the protein kinase domain of the Egfr protein between amino acids 773 and 774 (UniProt.org, PMID: 23371856). H773_V774insAH has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertion mutations (PMID: 24353160).

 
III. Representative Data

1. Anti-proliferation assay

 

 

Figure . Anti-proliferation assay of three reference compounds on the EGFR H773_V774insAH/BaF3 Stable Cell Line

 

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