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药靶细胞株 > kinase激酶细胞株 > CBP73220EGFR H773_V774insAH/BaF3

EGFR H773_V774insAH/BaF3
名称 EGFR H773_V774insAH/BaF3
型号 CBP73220
报价
特点 EGFR H773_V774insAH/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO
  • 详细内容
CBP73220
I. Introduction

Cell Line Name:

EGFR H773_V774insAH/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

EGFR H773_V774insAH results in the insertion of two amino acids within the drug-binding pocket in the protein kinase domain of the Egfr protein between amino acids 773 and 774 (UniProt.org, PMID: 23371856). H773_V774insAH has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertion mutations (PMID: 24353160).

III. Representative Data

1. WB of EGFR H773_V774insAH/BaF3

CBP73220-1.jpg


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