EGFR S768_V769delinsIL（S768I/V769L）/BaF3-南京科佰生物科技有限公司

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名称	EGFR S768_V769delinsIL（S768I/V769L）/BaF3
型号	CBP73181
报价
特点	EGFR S768_V769delinsIL（S768I/V769L）/BaF3,母细胞：BaF3，冻存条件：90% FBS+10% DMSO

CBP73181
I. Introduction
Cell Line Name：	EGFR S768_V769delinsIL(S768I&V769L)/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS+2ug/ml puromycin
Mycoplasma Status:	Negative

II.Background
EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR S768_V769delinsIL results in a deletion of two amino acids in the protein kinase domain of the Egfr protein from aa 768 to aa 769, combined with the insertion of an isoleucine (I) and a leucine (L) at the same site (UniProt.org). S768_V769delinsIL has been identified in the scientific literature (PMID: 17045698, PMID: 27304188), but has not been biochemically characterized and therefore, its effect on Egfr protein function is unknown (PubMed, Jul 2019).

III. Representative Data
1. WB of EGFR S768_V769delinsIL(S768I&V769L)/BaF3
2. Anti-proliferation assay