名称 | EGFR V769_D770insASV/BaF3 |
型号 | CBP73176 |
报价 | ![]() |
特点 | EGFR V769_D770insASV/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO |
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药靶细胞株 > kinase激酶细胞株 > CBP73176EGFR V769_D770insASV/BaF3
![EGFR V769_D770insASV/BaF3](http://img80.chem17.com/gxhpic_a89b1029a6/fd9c5b6de14e75b1eafd7ea18ebce581b3ffb67da0e34310505290994c621a9eb8eec7d9fa03e8d2.jpg)
- 详细内容
CBP73176 | |
I. Introduction | |
Cell Line Name: | EGFR V769_D770insASV/BaF3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
II.Background | |
EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR V769_D770insASV results in the insertion of three amino acids in the protein kinase domain of the Egfr protein between amino acids 769 and 770 (UniProt.org). V769_D770insASV has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions. | |
III. Representative Data | |
1.WB of EGFR expression | |
2. Sanger Sequencing of EGFR V769_D770insASV | |
3. Anti-proliferation assay Figure 3 . Anti-proliferation assay of three reference compounds on the EGFR V769_D770insASV/BaF3 Stable Cell Line. |