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药靶细胞株 > kinase激酶细胞株 > CBP73176EGFR V769_D770insASV/BaF3

EGFR V769_D770insASV/BaF3
名称 EGFR V769_D770insASV/BaF3
型号 CBP73176
报价
特点 EGFR V769_D770insASV/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO
  • 详细内容


CBP73176
I. Introduction

Cell Line Name:

EGFR V769_D770insASV/BaF3

Host Cell:

Ba/F3

Stability:16 passages

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR V769_D770insASV results in the insertion of three amino acids in the protein kinase domain of the Egfr protein between amino acids 769 and 770 (UniProt.org). V769_D770insASV has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions.

III. Representative Data

1.WB of EGFR expression

CBP73176-1.png


2. Sanger Sequencing of EGFR V769_D770insASV


CBP73176-2.png


3. Anti-proliferation assay

CBP73176-3.png



Figure 3 . Anti-proliferation assay of three reference compounds on the EGFR V769_D770insASV/BaF3 Stable Cell Line.



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