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药靶细胞株 > kinase激酶细胞株 > CBP73211ETV6-NTRK3 G623R/BaF3

ETV6-NTRK3 G623R/BaF3
名称 ETV6-NTRK3 G623R/BaF3
型号 CBP73211
报价
特点 ETV6-NTRK3 [G623R]/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO,培养基:1640+10%FBS+2ug/ml puromycin
  • 详细内容


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CBP73211
I. Introduction

Cell Line Name:

ETV6-NTRK3 [G623R]/BaF3

Host Cell:

BA/F3

Stability:16 passages

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
II.Background

ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) of chromosome 12 at position p13.2 (i.e. 12p13.2) and the NTRK3 gene located on the long arm (designated q) of chromosome 15 at position q25.3 (i.e. 15q25.3) to create the (12;15)(p13;q25) fusion gene, ETV6-NTRK3. This new gene consists of the 5' end of ETV6 fused to the 3' end of NTRK3. ETV6-NTRK3 therefore codes for an chimeric oncoprotein consisting of the helix-loop-helix (HLH) protein dimerization domain of the ETV6 protein fused to the tyrosine kinase (i.e. PTK) domain of the NTRK3 protein. The ETV6 gene codes for the transcription factor protein, ETV6, which suppresses the expression of, and thereby regulates, various genes that in mice are required for normal hematopoiesis as well as the development and maintenance of the vascular network. NTRK3 codes for Tropomyosin receptor kinase C a NT-3 growth factor receptor cell surface protein that when bound to its growth factor ligand, neurotrophin-3, becomes an active tyrosine kinase that phosphorylates tyrosine residues on, and thereby stimulates, signaling proteins that promote the growth, survival, and proliferation of their parent cells. The tyrosine kinase of the ETV6-NTRK3 fusion protein is dysfunctional in that it is continuously active in phophorylating tyrosine residues on, and thereby continuously stimulating, proteins that promote the growth, survival, and proliferation of their parent cells. In consequence, these cells take on malignant characteristics and are on the pathway of becoming cancerous. Indeed, the ETV6-NTRK3 fusion gene appears to be a critical driver of several types of cancers. It was originally identified in congenital fibrosarcoma and subsequently found in secretory breast cancer (also termed juvenile breast cancer), Mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, and radiation-induced papillary thyroid carcinoma.

 
III. Representative Data

1.Sanger of ETV6-NTRK3 [G623R]/BaF3

 

Figure 1. Breakpoint of  ETV6-NTRK3-G623R/BaF3

 

CBP73211.png

Figure 2. SNP of  ETV6-NTRK3-G623R/BaF3

2. Anti-proliferation assay

 

 

CBP73211-2.jpg

     

 

 

 

Figure3. Anti-proliferation assay of two reference compounds on the ETV6-NTRK3-G623R/BaF3 Stable Cell Line


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