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药靶细胞株 > 免疫治疗细胞株 > CBP74084CTLA4/IL2 Promoter Reporter/Jurkat

CTLA4/IL2 Promoter Reporter/Jurkat
名称 CTLA4/IL2 Promoter Reporter/Jurkat
型号 CBP74084
报价
特点 CTLA4/IL2 Promoter Reporter/Jurkat,冻存条件:90% FBS+10% DMSO;
  • 详细内容

CTLA4/IL2 Promoter Reporter/Jurkat

CBP74084
I. Background

CTLA4 is a member of the immunoglobulin superfamily. It is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells.

 
II. Description
Recombinant Jurkat T cell expressing firefly luciferase gene under the control of IL-2 promoter with constitutive expression of human CTLA4 (Cytotoxic T-Lymphocyte Associated Protein, CD152; GenBank Accession #NM_005214).
 
III. Introduction
Host Cell:Jurkat
Expressed gene:

CTLA4/IL2

Stability:32 passages
Synonym(s):Cytotoxic T-lymphocyte-associated protein 4, CD152
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

 

Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):·Screen for activators or inhibitors of CTLA4 signaling in a cellular context
·Characterize the biological activity of CTLA4 and its interactions with ligands
 
IV. Description of Host Cell Line
Organism:Homo sapiens, human
Tissue:Peripheral blood
Disease: Childhood T acute lymphoblastic leukemia
Morphology: Lymphoblast
Growth Properties: Suspension
 
Ⅴ. Representative Data

 

Figure 1. Recombinant Jurkat stably expressing human CTLA4/IL2 Promoter Reporter.

Figure 2. Dose Response of lpilimumab in CTLA4/IL2 Promoter Reporter-Jurkat Cells (C39) with TCR Activitor Cell, the EC50=2.53ug/ml .

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