HVEM/TCR Activator/CHO-南京科佰生物科技有限公司

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联系人：蒋经理
电话：86-25-86880024
号码：86-25-86880024
手机：18066071954
地址：南京市雨花区长虹路222号
Email： duhaitao@cobioer.com

名称	HVEM/TCR Activator/CHO
型号	CBP74082
报价
特点	HVEM/TCR Activator/CHO，冻存条件：90% FBS+10% DMSO；

CBP74082
I. Background
HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.

II. Introduction
Expressed gene:	HVEM
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):	HVEM, TNFRSF14, CD270, HVEA, TR2, LIGHTR
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	F12K+10%FBS+600ug/ml hygromycin+2ug/ml puromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay

III. Representative Data
Figure 1. Recombinant HVEM/TCR Activator/CHO constitutively expressing HVEM. Figure 2. Dose Response of BTLA Blocking Antibody in BTLA Effector Reporter Cells (Clone 1) With HVEM /TCR Activator - CHO Cells. Figure 3. Dose Response of BTLA Blocking Antibody in BTLA Effector Reporter Cells (Clone 1) With HVEM/TCR Activator - CHO Cells.