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药靶细胞株 > 肿瘤免疫细胞株 > CBP74082HVEM/TCR Activator/CHO

HVEM/TCR Activator/CHO
名称 HVEM/TCR Activator/CHO
型号 CBP74082
报价
特点 HVEM/TCR Activator/CHO,冻存条件:90% FBS+10% DMSO;
  • 详细内容
CBP74082
I. Background
HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.
II. Introduction
Expressed gene:HVEM
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):HVEM
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+600ug/ml hygromycin+2ug/ml puromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
III. Representative Data



 COBIOER

Figure 1. Recombinant HVEM/TCR Activator/CHO constitutively expressing HVEM.




Figure 2. Dose Response of BTLA Blocking Antibody in BTLA Effector Reporter Cells (Clone 1) With HVEM /TCR Activator - CHO Cells.


 COBIOER


Figure 3. Dose Response of BTLA Blocking Antibody in BTLA Effector Reporter Cells (Clone 1) With HVEM/TCR Activator - CHO Cells.

     


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