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药靶细胞株 > 肿瘤免疫细胞株 > CBP74079LAG3/IL2-Luc/Jurkat

LAG3/IL2-Luc/Jurkat
名称 LAG3/IL2-Luc/Jurkat
型号 CBP74079
报价
特点 LAG3/IL2-Luc/Jurkat,冻存条件:90% FBS+10% DMSO;
  • 详细内容

LAG3/IL2-Luc/Jurk

CBP74079
I. Background

Lymphocyte-activation gene 3 (LAG3, CD223) is a cell surface protein that belongs to immunoglobulin (Ig) superfamily. LAG3 is expressed on activated T cells, natural killer cells, B cells, and plasmacytoid dendritic cells.

II. Description
Recombinant Jurkat T cell expressing firefly luciferase gene under the control of IL-2 response elements with constitutive expression of human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286).
III. Introduction
Host Cell:Jurkat
Expressed gene:

LAG3-IL2

Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):LAG3, LAG-3, Jurkat
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

RPMI-1640+10%FBS+1ug/ml puromycin+10ug/ml blasticidin

Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):

·Screen for activators or inhibitors of LAG3 signaling in a cellular context
·Characterize the biological activity of LAG3 and its interactions with ligands

IV. Description of Host Cell Line
Organism:Human
Tissue:Peripheral blood
Disease: Childhood T acute lymphoblastic leukemia
Morphology: Lymphoblast
Growth Properties: Suspension
Ⅴ. Representative Data

 COBIOER

Figure 1. Recombinant Jurkat stably expressing human LAG3.

CBP74079-2.jpg

Figure 2.  Dose Response of Anti-LAG3 Neutralizing Antibody in LAG3/lL2 Promoter Reporter-Jurkat Cells, the EC50=2.99ug/ml.








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