| 名称 | RANK Effector Reporter Cell |
| 型号 | CBP74125 |
| 报价 |  |
| 特点 | RANK Effector Reporter Cell，冻存条件：90% FBS+10% DMSO； |
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电话：86-25-86880024
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Email： zhangxiangwen@cobioer.com
电话：86-25-86880024
号码：86-25-86880024
手机：18066071954
地址：南京市雨花区长虹路222号
Email： zhangxiangwen@cobioer.com
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- 详细内容
| CBP74125 | |
| I. Background | |
| RANK/RANKL/OPG pathway plays a significant role in osteoclast maturation, which are the major cells in charge of bone resorption. If RANKL binds to the receptor RANK instead of binding to its decoy receptor Osteoprotegerin (OPG), it activates the NF-κB pathway to promote osteoclast survival and proliferation, resulting in the resorption of bone. Therefore, abnormal production of RANKL or OPG can cause osteoporosis and other bone-related disorders, making the RANKL/RANK signaling pathway a valuable target for drug development. | |
| II. Introduction | |
| Expressed gene: | RANK |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | MEM+10%FBS+NEAA+NaP+200ug/ml hygromycin+1ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
Figure 1. Dose response of Human Recombinant RANKL in RANK Effector Reporter Cell Line (C31).
Figure 2. lnhibition of RANKL-induced Reporter Activity by RANKL Neutralizing Antibody in RANK Effector Reporter Cells (Clone31). | |
