RANK Effector Reporter Cell-南京科佰生物科技有限公司

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Email： zhangxiangwen@cobioer.com

名称	RANK Effector Reporter Cell
型号	CBP74125
报价
特点	RANK Effector Reporter Cell，冻存条件：90% FBS+10% DMSO；

CBP74125
I. Background
RANK/RANKL/OPG pathway plays a significant role in osteoclast maturation, which are the major cells in charge of bone resorption. If RANKL binds to the receptor RANK instead of binding to its decoy receptor Osteoprotegerin (OPG), it activates the NF-κB pathway to promote osteoclast survival and proliferation, resulting in the resorption of bone. Therefore, abnormal production of RANKL or OPG can cause osteoporosis and other bone-related disorders, making the RANKL/RANK signaling pathway a valuable target for drug development.

II. Introduction
Expressed gene:	RANK
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	MEM+10%FBS+NEAA+NaP+200ug/ml hygromycin+1ug/ml puromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay

III. Representative Data
Figure 1. Dose response of Human Recombinant RANKL in RANK Effector Reporter Cell Line (C31). Figure 2. lnhibition of RANKL-induced Reporter Activity by RANKL Neutralizing Antibody in RANK Effector Reporter Cells (Clone31).