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药靶细胞株 > 免疫治疗细胞株 > CBP74125RANK Effector Reporter Cell

RANK Effector Reporter Cell
名称 RANK Effector Reporter Cell
型号 CBP74125
报价
特点 RANK Effector Reporter Cell,冻存条件:90% FBS+10% DMSO;
  • 详细内容

 RANK Effector Reporter Cell

CBP74125
I. Background
RANK/RANKL/OPG pathway plays a significant role in osteoclast maturation, which are the major cells in charge of bone resorption. If RANKL binds to the receptor RANK instead of binding to its decoy receptor Osteoprotegerin (OPG), it activates the NF-κB pathway to promote osteoclast survival and proliferation, resulting in the resorption of bone. Therefore, abnormal production of RANKL or OPG can cause osteoporosis and other bone-related disorders, making the RANKL/RANK signaling pathway a valuable target for drug development.
 
II. Introduction
Expressed gene:RANK
Stability:32 passages
Freeze Medium:90% FBS+10% DMSO
Culture Medium: 
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
 
III. Representative Data

Figure 1. Dose response of Human Recombinant RANKL in RANK Effector Reporter Cell Line (C31).


Figure 2lnhibition of RANKL-induced Reporter Activity by RANKL Neutralizing Antibody in RANK Effector Reporter Cells (Clone31).

 

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