CLEC2D aAPC Cell-南京科佰生物科技有限公司

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Email： zhangxiangwen@cobioer.com

CBP74138
I. Background
CLEC2D (C-type lectin domain family 2 member D) is also known as CLAX, LLT1, OCIL is receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis, inhibits osteoclast formation, inhibits bone resorption and modulates the release of interferon-gamma. It is also a ligand for the human NKR-P1A (CD161) receptor, present on NK cells and T cells. Furthermore, The reference shows the pathway may as a potential immunotherapy targets.

II. Introduction
Expressed gene:	CLEC2D
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	F12K+10%FBS+600ug/ml hygromycin+2ug/ml puromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay


III. Representative Data
Figure 1. Dose Response of CD161 Blocking Antibody in CD161 Effector Reporter Cells (Clone 8) With CLEC2D aAPC Cells.