名称 | BCR-ABL1 E459K/BaF3 |
型号 | CBP73302 |
报价 | |
特点 | BCR-ABL1 [E459K]/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO;ABL1 是一种酪氨酸激酶,在正常细胞中,它在细胞分化和细胞周期调节中发挥作用。 BCR-ABL1 融合基因产生一种组成型活性酪氨酸激酶,导致不受控制的增殖。 |
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药靶细胞株 > kinase激酶细胞株 > CBP73302BCR-ABL1 E459K/BaF3
- 详细内容
CBP73302 | |
I. Introduction | |
Cell Line Name: | BCR-ABL1 [E459K]/BaF3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
II.Background | |
Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia chromosome. In rare CML cases lacking the traditional t(9;22) translocation, other translocations result in the creation of the BCR-ABL1 fusion gene, which sometimes involve multiple chromosomes. | |
III. Representative Data | |
1.WB of BCR-ABL1 [E459K]/BaF3 | |
2.Sanger of BCR-ABL1 [E459K]/BaF3 Figure 2. BCR-ABL1 [E459K]/BaF3 E549K
Figure 3. BCR-ABL1 [E459K]/BaF3 Fusion | |
3. Anti-proliferation assay Figure 4. CTG Proliferation Assay of BaF3 BCR-ABL1 E459K Cells (C8). | |