加入收藏 | 设为首页 | 联系我们

产品搜索

相关文章

联系我们

联系人:蒋经理
电话:86-25-86880024
号码:86-25-86880024
手机:18066071954
地址:南京市雨花区长虹路222号
Email: zhangxiangwen@cobioer.com

产品展示 / PRODUCTS
药靶细胞株 > kinase激酶细胞株 > CBP73306BCR-ABL1 E355G/BaF3

BCR-ABL1 E355G/BaF3
名称 BCR-ABL1 E355G/BaF3
型号 CBP73306
报价
特点 BCR-ABL1 [E355G]/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO;
  • 详细内容
CBP73306
I. Introduction

Cell Line Name:

BCR-ABL1 [E355G]/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

 
II.Background

Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia chromosome. In rare CML cases lacking the traditional t(9;22) translocation, other translocations result in the creation of the BCR-ABL1 fusion gene, which sometimes involve multiple chromosomes.
ABL1 is a tyrosine kinase, and, in normal cells, it plays a role in cellular differentiation and regulation of the cell cycle. The BCR-ABL1 fusion gene creates a constitutively active tyrosine kinase, which leads to uncontrolled proliferation.

 
III. Representative Data

1.WB of BCR-ABL1 [E355G]/BaF3

2.Sanger of BCR-ABL1 [E355G]/BaF3

 

Figure 2. BCR-ABL1 [E355G]/BaF3 E355G

 

Figure 3. BCR-ABL1 [E355G]/BaF3 Fusion

3.  Anti-proliferation assay

Figure 4. CTG Proliferation Assay of BaF3 BCR-ABL1 E355G Cells (C11).

 
 

如果你对CBP73306BCR-ABL1 E355G/BaF3感兴趣,想了解更详细的产品信息,填写下表直接与厂家联系:


留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7

化工仪器网

推荐收藏该企业网站