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药靶细胞株 > kinase激酶细胞株 > CBP73288BCR-ABL1 A337V/BaF3

BCR-ABL1 A337V/BaF3
名称 BCR-ABL1 A337V/BaF3
型号 CBP73288
报价
特点 BCR-ABL1 [E255V]/BaF3,母细胞:BaF3
  • 详细内容


CBP73288
I. Introduction

Cell Line Name:

BCR-ABL1 [E255V]/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative


II.Background

Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia chromosome. In rare CML cases lacking the traditional t(9;22) translocation, other translocations result in the creation of the BCR-ABL1 fusion gene, which sometimes involve multiple chromosomes.

ABL1 is a tyrosine kinase, and, in normal cells, it plays a role in cellular differentiation and regulation of the cell cycle. The BCR-ABL1 fusion gene creates a constitutively active tyrosine kinase, which leads to uncontrolled proliferation.


III. Representative Data

1. WB of  BCR-ABL1 [E255V]/BaF3

CBP73288 WB.jpg


2.Sanger of BCR-ABL1 [E255V]/BaF3

CBP73288 sanger1.png

Figure 2. BCR-ABL1 E255V


CBP73288 sanger2.png

Figure 3. BCR-ABL1 [E255V]/BaF3 Fusion

3. Anti-proliferation assay

CBP73288 fig.png

Figure 4. CTG Proliferation Assay of BaF3 BCR-ABL1 E255V Cells (C1).





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