c-Kit W557_K558del/BaF3-南京科佰生物科技有限公司

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联系人：蒋经理
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Email： zhangxiangwen@cobioer.com

名称	c-Kit W557_K558del/BaF3
型号	CBP73233
报价
特点	c-Kit W557_K558del/BaF3,母细胞：BaF3，KIT W557del 导致 Kit 蛋白近膜结构域（外显子 11）中氨基酸 557 处的氨基酸缺失（PMID：12918066）。 W557del 尚未表征，但类似的 Kit 外显子 11 缺失正在激活（PMID：9438854，PMID：9797363），因此预计会导致 Kit 蛋白功能的增加。

CBP73233
I. Introduction
Cell Line Name：	c-Kit W557_K558del/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Anti-proliferation assay and PD assay
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
KIT W557del results in the deletion of an amino acid in the juxtamembrane domain (exon 11) of the Kit protein at amino acids 557 (PMID: 12918066). W557del has not been characterized, however similar Kit exon 11 deletions are activating (PMID: 9438854, PMID: 9797363), and therefore, is predicted to lead to a gain of Kit protein function .

III. Representative Data
1. WB of c-Kit W557_K558del/BaF3
2.Sanger of c-Kit W557_K558del/BaF3
3. Anti-proliferation assay Figure 3. CTG Proliferation Assay of BaF3 c-KIT W557_ K558del (C2).