c-Kit_K642E-D816A/BaF3-南京科佰生物科技有限公司

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名称	c-Kit_K642E-D816A/BaF3
型号	CBP73294
报价
特点	c-Kit_K642E-D816A/BaF3,母细胞：BaF3，KIT K642E 位于 Kit 蛋白（PMID: 15990278）的酪氨酸激酶结构域 1（外显子 13）内。 K642E 导致 Kit 的组成型磷酸化和下游信号的激活（PMID：15990278，PMID：19802003），以及培养细胞的转化（PMID：11073817）。

CBP73294
I. Introduction
Cell Line Name：	c-Kit K642E-D816A/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Anti-proliferation assay and PD assay
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
KIT K642E lies within the tyrosine kinase domain 1 (exon 13) of the Kit protein (PMID: 15990278). K642E results in constitutive phosphorylation of Kit and activation of downstream signaling (PMID: 15990278, PMID: 19802003), as well as transformation of cultured cells (PMID: 11073817).

III. Representative Data
1.Sanger of c-Kit K642E-D816A/BaF3 Figure 1. c-Kit_K642E-D816A/BaF3 K642E Figure 2. c-Kit K642E-D816A/BaF3 D816A
2. Anti-proliferation assay Figure 3. CTG Proliferation Assay of BaF3 c-KIT K642E/D816A (C5).