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药靶细胞株 > kinase激酶细胞株 > CBP73214CCDC6-RET WT/BaF3

CCDC6-RET WT/BaF3
名称 CCDC6-RET WT/BaF3
型号 CBP73214
报价
特点 CCDC6-RET WT/BaF3,母细胞:BaF3
  • 详细内容


CBP73214
I. Introduction

Cell Line Name:

CCDC6-RET WT/BaF3

Host Cell:

BA/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS+1ug/ml puromycin

Mycoplasma Status:

Negative


II.Background

CCDC6, coiled-coil domain containing 6, has been shown to play a role in the DNA damaging signaling pathway acting as a substrate of ATM (PMID: 17420723). CCDC6 fusions with RET (PMID: 23154560, PMID: 26078337) and BRAF (PMID: 26314551) have been observed in multiple cancer types.


III. Representative Data

1. WB of  CCDC6-RET WT/BaF3WT

2. Sanger of CCDC6-RET WT/BaF3

Figure 2. Breakpoint of CCDC6-RET WT/BaF3

2. Anti-proliferation assay


Figure 3. CTG assay of  for CCDC6-RET WT/BaF3 Stable Cell Line,the Gi50 was 137.3nM.



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