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药靶细胞株 > kinase激酶细胞株 > CBP73215CCDC6-RET V804L/BaF3激酶细胞

CCDC6-RET V804L/BaF3激酶细胞
名称 CCDC6-RET V804L/BaF3激酶细胞
型号 CBP73215
报价
特点 CCDC6-RET V804L/BaF3激酶细胞
  • 详细内容

CCDC6-RET V804L/BaF3激酶细胞

CBP73215

I. Introduction

Cell Line Name:

CCDC6-RET [V804L]/BaF3

Host Cell:

BA/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS+1ug/ml puromycin

Mycoplasma Status:

Negative

II.Background

CCDC6, coiled-coil domain containing 6, has been shown to play a role in the DNA damaging signaling pathway acting as a substrate of ATM (PMID: 17420723). CCDC6 fusions with RET (PMID: 23154560, PMID: 26078337) and BRAF (PMID: 26314551) have been observed in multiple cancer types.

III. Representative Data

1.WB of CCDC6-RET V804L/BaF3

CBP73215 WB.jpg


2. Sanger of CCDC6-RET [V804L]/BaF3

CBP73215 sanger1.png


Figure 2. Breakpoint of CCDC6-RET V804L/BaF3

CBP73215 sanger2.png


Figure 3. Point mutation of CCDC6-RET V804L/BaF3

3. Anti-proliferation assay

CBP73215 fig.jpg


Figure 4. Anti-proliferation assay of one reference compounds on the CCDC6-RET V804L/BaF3 Stable Cell Line.





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