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药靶细胞株 > kinase激酶细胞株 > CBP73046EGFR Del19-T790M/BaF3

EGFR Del19-T790M/BaF3
名称 EGFR Del19-T790M/BaF3
型号 CBP73046
报价
特点 EGFR Del19-T790M/BaF3,母细胞:BaF3,培养基:RPMI-1640+10% FBS
  • 详细内容
CBP73046
I. Introduction

Cell Line Name:

EGFR Del19-T790M/BaF3

Gene Synonyms:

Epidermal Growth Factor Receptor, ERBB1, EGFR

Host Cell:

Ba/F3

Stability:16 passages

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10% FBS

Mycoplasma Status:

Negative


II.Background

EGFR is widely recognized for its importance in cancer. Amplification and mutations have been shown to be driving events in many cancer types. Its role in non-small cell lung cancer, glioblastoma and basal-like breast cancers has spurred many research and drug development efforts. Tyrosine kinase inhibitors have shown efficacy in EGFR amplfied tumors, most notably gefitinib and erlotinib. Mutations in EGFR have been shown to confer resistance to these drugs, particularly the variant T790M, which has been functionally characterized as a resistance marker for both of these drugs. The later generation TKI's have seen some success in treating these resistant cases, and targeted sequencing of the EGFR locus has become a common practice in treatment of non-small cell lung cancer. Overproduction of ligands is another possible mechanism of activation of EGFR. ERBB ligands include EGF, TGF-a, AREG, EPG, BTC, HB-EGF, EPR and NRG1-4 (for detailed information please refer to the respective ligand section). In ligand-activated cancers, Cetuximab appears to be more effective than tyrosine-kinase inhibitors.


III. Representative Data

1.WB of EGFR Del19-T790M/BaF3

73046-1.png


2.Sanger of EGFR Del19-T790M/BaF3

73046.jpg

73046-2.jpg


3. Anti-proliferation assay

73046-4.png

Figure 4. Anti-proliferation assay of three reference compounds on the EGFR Del19-T790M/BaF3 Stable Cell Line.



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