名称 | CD112/TCR Activator/CHO |
型号 | CBP74121 |
报价 | ![]() |
特点 | CD112/TCR Activator/CHO,冻存条件:90% FBS+10% DMSO |
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- 详细内容
I. Background | |
PVRIG(CD112R),是脊髓灰质炎病毒受体(PVR)家族的共抑制受体,在自然杀伤细 胞(NK)和 T 细胞上表达。它与其配体(CD112 或 PVRL2/nectin-2)结合,抑制 T 细胞和 NK 细胞对癌症的反应。因此,CD112R 作为一种新的免疫检查点抑制剂在癌症治疗 具有很高的潜力。 | |
II. Description | |
CD112 TCR Activator CHO 细胞作为 PVRIG(CD112R) Effector Reporter Cell 的靶细胞, 很好的模拟了体内 PVRIG(CD112R) 的信号转导过程,原理见下图所示。
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III. Introduction | |
Expressed gene: | CD112 |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Synonym(s): | Nectin-2, Herpes virus entry mediator B, HVEB, PVRL2, and PRR2 |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | F12K+10%FBS+600μg/ml hygromycin+2μg/ml puromycin |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
Application(s): | Functional(Report Gene) Assay |
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IV. Representative Data | |
Figure 2. Recombinant CHO-cells constitutively expressing CD112. | |
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Figure 3. Dose Response of PVRIG Blocking Antibody in PVRIG(CD112R) Effector Reporter Cell(C7) With CD112/TCR Activator - CHO Cells. |