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药靶细胞株 > 免疫治疗细胞株 > CBP74070CD86/CHO

CD86/CHO
名称 CD86/CHO
型号 CBP74070
报价
特点 CD86/CHO,冻存条件:90% FBS+10% DMSO,培养基:F12K+10%FBS+500ug/ml hygromycin
  • 详细内容

 

CBP74070
I. Background
B7-2 (CD86) signaling through CTLA4 (CD152) has been shown to inhibit T- cell activation. This co-inhibitory pathway can be overactive in many tumors, enabling cancers to escape the host’s immune system. CTLA4-blocking antibodies, including Ipilimumab (Yervoy) and Tremelimumab, have shown clinical efficacy in treating cancer.
 
II. Description

CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Gallbladder Squamous Cell Carcinoma and Myocarditis. Among its related pathways are Allograft rejection and PI3K/AKT activation. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and coreceptor activity.

 
III. Introduction
Host Cell:CHO
Expressed gene:CD86
Stability:32 passages
Synonym(s):

T-lymphocyte activation antigen CD86, B7.2, FUN-1, B70, BU63, CD86, B72

Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+500ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Useful for studying protein binding and screening small molecules.
 
IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data

 

CBP74070.png

 Figure 1.Recombinant CHO-cells constitutively expressing  CD86 and an engineered T cell receptor (TCR) activator.

 

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