| 名称 | CD86/CHO |
| 型号 | CBP74070 |
| 报价 |  |
| 特点 | CD86/CHO，冻存条件：90% FBS+10% DMSO,培养基：F12K+10%FBS+500ug/ml hygromycin |
产品搜索
相关文章
联系我们
联系人：蒋经理
电话：86-25-86880024
号码：86-25-86880024
手机：18066071954
地址：南京市雨花区长虹路222号
Email： duhaitao@cobioer.com
电话：86-25-86880024
号码：86-25-86880024
手机：18066071954
地址：南京市雨花区长虹路222号
Email： duhaitao@cobioer.com
产品展示 / PRODUCTS
- 详细内容
| CBP74070 | |
| I. Background | |
| B7-2 (CD86) signaling through CTLA4 (CD152) has been shown to inhibit T- cell activation. This co-inhibitory pathway can be overactive in many tumors, enabling cancers to escape the host’s immune system. CTLA4-blocking antibodies, including Ipilimumab (Yervoy) and Tremelimumab, have shown clinical efficacy in treating cancer. | |
| II. Description | |
CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Gallbladder Squamous Cell Carcinoma and Myocarditis. Among its related pathways are Allograft rejection and PI3K/AKT activation. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and coreceptor activity. | |
| III. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | CD86 |
| Stability: | 32 passages |
| Synonym(s): | T-lymphocyte activation antigen CD86, B7.2, FUN-1, B70, BU63, CD86, B72 |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+500ug/ml hygromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Useful for studying protein binding and screening small molecules. |
| IV. Description of Host Cell Line | |
| Organism: | Cricetulus griseus, hamster, Chinese |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
Figure 1.Recombinant CHO-cells constitutively expressing CD86 and an engineered T cell receptor (TCR) activator. | |
