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药靶细胞株 > 免疫治疗细胞株 > CBP74046CTLA4/HEK293

CTLA4/HEK293
名称 CTLA4/HEK293
型号 CBP74046
报价
特点 CTLA4/HEK293,冻存条件:90% FBS+10% DMSO,培养基:DMEM+10%FBS+100ug/ml hygromycin
  • 详细内容
CBP74046
I. Background
CTLA4 is a member of the immunoglobulin superfamily. It is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands and act as an “off" switch when bound to CD80 or CD86. Not surprisingly, CTLA-4 is an important drug target for the regulation of the host’s response to cancer.

II. Description
Recombinant HEK293 stably expressing human CTLA4 (Cytotoxic T-Lymphocyte Associated Protein; CD152), GenBank Accession #NM_005214.

III. Introduction
Host Cell:HEK293
Expressed gene:CTLA4
Stability:32 passages
Synonym(s):Cytotoxic T-lymphocyte-associated protein 4, CD152
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

DMEM+10%FBS+100ug/ml hygromycin

Mycoplasma Testing:Negative
Storage:Immediately upon receipt, store in liquid nitrogen.
Application(s):Screening for CTLA4 binding molecules (such as anti-CTLA4 antibody) in a cellular context

IV. Description of Host Cell Line
Organism:Homo sapiens,human
Tissue:Embryonic kidney
Disease: Normal
Morphology: Epitheloid cell
Growth Properties: Adherent

Ⅴ. Representative Data

CBP74046.png

Figure 1.Recombinant HEK293 stably expressing human CTLA4(Cytotoxic T-Lymphocyte Associated Protein; CD152), GenBank Accession #NM_005214.



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