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药靶细胞株 > 免疫治疗细胞株 > CBP74047HVEM/HEK293

HVEM/HEK293
名称 HVEM/HEK293
型号 CBP74047
报价
特点 HVEM/HEK293,冻存条件:90% FBS+10% DMSO;培养基:DMEM+10%FBS+1ug/ml puromycin
  • 详细内容


HVEM/HEK293

CBP74047

I. Background
HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Alternately, interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.
 
II. Description
Recombinant HEK293 stably expressing human HVEM (Herpesvirus entry mediator; CD270; TNFRSF14; ATAR) GenBank Accession # NM_003820).
 
III. Introduction
Host Cell:HEK293
Expressed gene:HVEM
Stability:32 passages
Synonym(s):Immunotherapy, CD270, Herpesvirus entry mediator, HVEM, HEK293, HVEM - HEK293, TNFRSF14, BTLA
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

DMEM+10%FBS+1ug/ml puromycin

Mycoplasma Testing:Negative
Storage:Immediately upon receipt, store in liquid nitrogen.
Application(s):·HVEM binding molecule (such as anti-HVEM antibody) screening and profiling in a cellular context

·Binding studies using HVEM ligands

 
IV. Description of Host Cell Line
Organism:Homo sapiens,human
Tissue:Embryonic kidney
Disease: Normal
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data
 

Figure 1.Recombinant HEK293 stably expressing human HVEM (Herpesvirus entry mediator; CD270; TNFRSF14; ATAR) GenBank Accession # NM_003820).


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