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药靶细胞株 > 免疫治疗细胞株 > CBP74052LAG3/CHO

LAG3/CHO
名称 LAG3/CHO
型号 CBP74052
报价
特点 LAG3/CHO,冻存条件:90% FBS+10% DMSO;培养基:F12K+10%FBS+400ug/ml hygromycin
  • 详细内容

LAG3/CHO

CBP74052
I. Background
Lymphocyte-activation gene 3 (LAG3, CD223) is a cell surface protein that belongs to immunoglobulin (Ig) superfamily. LAG3 is expressed on activated T cells, natural killer cells, B cells, and plasmacytoid dendritic cells. Its main ligand is MHC class II, to which it binds with higher affinity than CD4. It negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1, and has been reported to play a role in Treg suppressive function. A number of LAG3 antibodies are in preclinical development for treatments for cancer and autoimmune disorders. LAG3 may be a better immune checkpoint inhibitor target than CTLA-4 or PD-1 since antibodies to these two checkpoints are only activating effector T cells, and not inhibiting Treg activity where an antagonist LAG3 antibody can both activate effector T cells (by downregulating the LAG3 inhibiting signal) and inhibit induced (i.e. antigen-specific) Treg suppressive activity.
 
II. Description
Recombinant CHO cells constitutively expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286).
 
III. Introduction
Host Cell:CHO
Expressed gene:LAG3
Stability:32 passages
Synonym(s):LAG3, LAG-3, CD223
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+400ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):This cell line is useful for LAG3 binding assays, flow cytometry, or for screening for LAG3 antibodies.
 
IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data

Figure Recombinant CHO cells constitutively expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286).

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