ICOS Effector Reporter Cell-南京科佰生物科技有限公司

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名称	ICOS Effector Reporter Cell
型号	CBP74063
报价
特点	ICOS Effector Reporter Cell，冻存条件：90% FBS+10% DMSO；

ICOS Effector Reporter Cell

CBP74063
I. Background
ICOS is a costimulatory molecule of the CD28 cell surface receptor superfamily that is expressed on activated T-cells. ICOS is involved in T-cell responses upon binding with its ligand, ICOSL (also known as B7-H2, CD275), which is normally expressed on B-cells, dendritic cells and monocytes.

II. Description
ICOS expression confers an activated phenotype and a strong suppressive capacity to intra-tumoral regulatory T-cells. The ICOS/ICOSL pathway is a key target for cancer immunotherapy.

III. Introduction
Expressed gene:	ICOS
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):	T-cell costimulator, CD278
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	RPMI-1640+10%FBS+800ug/ml hygromycin+10ug/ml blasticidin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay


IV. Representative Data
Figure 1. Dose response of Anti-lCOS Ab in ICOS Effector Reporter Cells(C5).