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药靶细胞株 > kinase激酶细胞株 > CBP73321BCR-ABL1 G250E/BaF3

BCR-ABL1 G250E/BaF3
名称 BCR-ABL1 G250E/BaF3
型号 CBP73321
报价
特点 BCR-ABL1 [G250E]/BaF3
  • 详细内容

 

CBP73321
I. Introduction

Cell Line Name:

BCR-ABL1 [G250E]/BaF3

Host Cell:

Ba/F3

Stability:16 passages

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

 

Mycoplasma Status:

Negative

 
II.Background

Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia chromosome. In rare CML cases lacking the traditional t(9;22) translocation, other translocations result in the creation of the BCR-ABL1 fusion gene, which sometimes involve multiple chromosomes.
ABL1 is a tyrosine kinase, and, in normal cells, it plays a role in cellular differentiation and regulation of the cell cycle. The BCR-ABL1 fusion gene creates a constitutively active tyrosine kinase, which leads to uncontrolled proliferation.

 
III. Representative Data

1.Sanger of BCR-ABL1 [G250E]/BaF3

 

2. Anti-proliferation assay

Figure 2. CTG Proliferation Assay of BaF3 BCR-ABL1 G250E Cells (C3).

 
 
 

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