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药靶细胞株 > kinase激酶细胞株 > CBP73314c-Kit V560Del/BaF3

c-Kit V560Del/BaF3
名称 c-Kit V560Del/BaF3
型号 CBP73314
报价
特点 c-Kit V560Del/BaF3
  • 详细内容

CBP73314

I. Introduction

Cell Line Name:

c-Kit V560Del/BaF3

Host Cell:

BA/F3

Stability:16 passages

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

 

Mycoplasma Status:

Negative

 
II.Background

KIT V560del (also reported as V559del) results in the deletion of an amino acid in the juxtamembrane domain (exon 11) of the Kit protein at amino acid 560 (PMID: 12879016). V560del confers a gain of function to Kit, resulting in constitutive, ligand independent phosphorylation of Kit and activation of Akt in cell culture (PMID: 15236194, PMID: 22282465), and transformation of cultured cells (PMID: 19861435).

 
III. Representative Data

1. Sanger of c-Kit V560Del/BaF3

 

2. Anti-proliferation assay

Figure 2.CTG Proliferation Assay of BaF3 c-KIT V560del (C7).

 

 

 

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