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药靶细胞株 > 肿瘤免疫细胞株 > CBP74144PD1-IL2 Pathway Effector Reporter Cell

PD1-IL2 Pathway Effector Reporter Cell
名称 PD1-IL2 Pathway Effector Reporter Cell
型号 CBP74144
报价
特点 PD1-IL2 Pathway Effector Reporter Cel 冻存条件:90% FBS+10% DMSO
  • 详细内容


CBP74144
I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
II. Introduction
Expressed gene:PD1-IL2
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:RPMI-1640+10%FBS+1ug/ml puromycin+800ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay
III. Representative Data


Figure 1. Dose Response of Anti-PD-L1 Blocking Antibody in PD-1-IL2 Pathway Effector Reporter Cells (C37) With Raji PD-L1 aAPC Cells.

Figure 2. Dose Response of Anti-PD-1 Blocking Antibody in PD-1-IL2 Pathway Effector Reporter Cells (C37) With Raji PD-L1 aAPC Cells.





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