名称 | AI-Edigene® FLT3 p.D835V Reference Standard P |
型号 | CBP10509 |
报价 | |
特点 | AI-Edigene® FLT3 p.D835V Reference Standard Plus |
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手机:18066071954
地址:南京市栖霞区纬地路9号
Email: zhangxiangwen@cobioer.com
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CBP10509 | |
Format | Genomic DNA |
Description | FLT3 D835V lies within the protein kinase domain activation loop of the Flt3 protein (PMID: 11290608). D835V results in constitutive phosphorylation of Flt3 and activation of Stat5, Erk signaling, leading to transformation of cultured cells (PMID: 15256420), and has been demonstrated to promote secondary drug resistance in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 22504184, PMID: 29187377). |
Technical Data | |
DNA Change | c.2504A>T |
AA Change | p.D835V |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Transcript | NM_004119.3 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |