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基因检测标准品 > Mutation > CBP10458CDKN2A p.L27fs Reference Standard 标准品

CDKN2A p.L27fs Reference Standard 标准品
名称 CDKN2A p.L27fs Reference Standard 标准品
型号 CBP10458
报价
特点 CDKN2A p.L27fs Reference Standard
  • 详细内容
 CBP10458
GeneCDKN2A
DescriptionCDKN2A, cyclin-dependent kinase inhibitor 2A, is a tumor suppressor (PMID: 30562755) that encodes p16 and p14ARF from alternate reading frames, which function to inhibit Cdk4 and Cdk6 and regulate Tp53 activity to promote cell-cycle arrest (PMID: 23875803, PMID: 17055429, PMID: 27428416). CDKN2A germline mutations are associated with familial atypical multiple mole melanoma and somatic mutations are highest in pancreatic, HNSCC, NSCLC, and melanoma (PMID: 27283171).
  
Technical Data 
DNA Changec.233_234delTC
AA Changep.L27fs
Mutation typeFrame_Shift_Del
ZygosityHomozygous
Allelic Frequency100.00%
TranscriptENST00000479692.2
Cosmic IDN/A
Chr position(GRCh37)chr9:21971125_21971124
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

10458.png

Storage4℃
Expiry36 months from the date of manufacture

 

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