名称 | HRAS p.G12V Reference Standard 标准品 |
型号 | CBP10289 |
报价 | |
特点 | HRAS p.G12V Reference Standard |
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CBP10289 | |
Format | Genomic DNA |
Description | HRAS G12V is hotspot mutation that lies within a GTP nucleotide binding region of the Hras protein (UniProt.org). G12V results in decreased Hras GTPase activity, loss of response to GTPase-activating proteins, leading to activation of downstream signaling pathways, and transformation of cultured cells (PMID: 24224811, PMID: 21850009, PMID: 6330729). |
Technical Data | |
DNA Change | c.35G>T |
AA Change | p.G12V |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Transcript | ENST00000397596 |
Cosmic ID | COSM483 |
Chr position(GRCh37) | chr11:534288 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |