名称 | PTEN p.R130* Reference Standard 标准品 |
型号 | CBP10120 |
报价 | ![]() |
特点 | PTEN p.R130* Reference Standard |
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CBP10120 | |
Format | Genomic DNA |
Description | PTEN R130* results in a premature truncation of the Pten protein at amino acid 130 of 403 within the phosphatase tensin-type domain (UniProt.org). R130* confers a loss of function to the Pten protein as demonstrated by decreased p53 signaling and increased DNA damage in xenografts (PMID: 24721394) and increased transformation ability in two different cell lines, as compared to wild-type Pten (PMID: 29533785). |
Technical Data | |
DNA Change: | c.388C>T |
AA Change | p.R130* |
Mutation type | Substitution - Nonsense |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Transcript | ENST00000371953 |
Cosmic ID | COSM5152 |
Chr position(GRCh37) | chr10:89692904 |
Buffer: | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |