名称 | STK11 p.KP178fs Reference Standard 标准品 |
型号 | CBP10465 |
报价 | ![]() |
特点 | STK11 p.KP178fs Reference Standard |
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CBP10465 | |
Gene | STK11 |
Description | STK11, serine/threonine kinase 11, is a tumor suppressor (PMID: 30562755) involved in cell metabolism, growth, polarity, and tumor suppression through the regulation of AMPK family members (PMID: 26398719). STK11 germline mutations are common in Peutz-Jeghers syndrome and somatic STK11 mutations have been identified in melanoma, lung, pancreatic, cervical, and endometrial cancers (PMID: 26877140, PMID: 29191602) and are often associated with resistance to immune checkpoint blockcade (PMID: 30626603). |
Technical Data | |
DNA Change | c.532_536delAAGCC |
AA Change | p.KP178fs |
Mutation type | Frame_Shift_Del |
Zygosity | Homozygous |
Allelic Frequency | 100.00% |
Transcript | ENST00000326873.7 |
Cosmic ID | N/A |
Chr position(GRCh37) | chr19:1220439_1220443 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |