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基因检测标准品 > Mutation > CBP10465STK11 p.KP178fs Reference Standard 标准品

STK11 p.KP178fs Reference Standard 标准品
名称 STK11 p.KP178fs Reference Standard 标准品
型号 CBP10465
报价
特点 STK11 p.KP178fs Reference Standard
  • 详细内容
 CBP10465
GeneSTK11
DescriptionSTK11, serine/threonine kinase 11, is a tumor suppressor (PMID: 30562755) involved in cell metabolism, growth, polarity, and tumor suppression through the regulation of AMPK family members (PMID: 26398719). STK11 germline mutations are common in Peutz-Jeghers syndrome and somatic STK11 mutations have been identified in melanoma, lung, pancreatic, cervical, and endometrial cancers (PMID: 26877140, PMID: 29191602) and are often associated with resistance to immune checkpoint blockcade (PMID: 30626603).
  
Technical Data 
DNA Changec.532_536delAAGCC
AA Changep.KP178fs
Mutation typeFrame_Shift_Del
ZygosityHomozygous
Allelic Frequency100.00%
TranscriptENST00000326873.7
Cosmic IDN/A
Chr position(GRCh37)chr19:1220439_1220443
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing 

CBP10465.png

Storage4℃
Expiry36 months from the date of manufacture

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