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基因检测标准品 > Mutation > CBP10140TP53 p.R248Q Reference Standard 标准品

TP53 p.R248Q Reference Standard 标准品
名称 TP53 p.R248Q Reference Standard 标准品
型号 CBP10140
报价
特点 TP53 p.R248Q Reference Standard
  • 详细内容

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 CBP10140
FormatGenomic DNA
DescriptionTP53 R248Q is a hotspot mutation that lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R248Q results in decreased transactivation of Tp53 targets and interference with wild-type Tp53 transactivation in cell culture, as well as increased Akt activation and enhanced tumor onset and growth in mouse models (PMID: 23538418, PMID: 16861262).
  
Technical Data 
DNA Change:c.743G>A
AA Changep.R248Q
Mutation typeSubstitution - Missense
ZygosityHomozygous
Allelic Frequency100%
TranscriptENST00000269305
Cosmic IDCOSM10662
Chr position(GRCh37)chr17:7577538
Buffer:Tris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

CBP10140.png

Storage4℃
Expiry36 months from the date of manufacture

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