hPD-L1/MC38-南京科佰生物科技有限公司

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CBPG0001
I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.

II. Introduction
Host Cell:	MC38
Expressed gene:	hPD-L1
Stability:	32 passages
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	DMEM+10%FBS+5ug/ml blasticidin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen

III. Description of Host Cell Line
Organism:	Mouse
Tissue:	Colon
Morphology:	Epitheloid cell
Growth Properties:	Adherent

IV. Representative Data
Figure 1. Recombinant hPD-L1/MC38 stably expressing hPD-L1.