PDGFRA V658A-V561A/BaF3细胞株-南京科佰生物科技有限公司

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Email： zhangxiangwen@cobioer.com

CBP73378
I. Introduction
Cell Line Name：	PDGFRA V658A-V561A/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
PDGFRA, platelet-derived growth factor receptor alpha, is a receptor tyrosine kinase that activates PI3K/Akt, RAS/MAPK, and JAK/STAT pathways to promote cell proliferation and survival (PMID: 21605429). PDGFRA mutations have been detected in melanoma, AML, peripheral nerve sheath tumors, sarcoma, and neuroendocrine carcinomas (PMID: 23752188, PMID: 20685895), several fusions have also been reported (PMID: 22432087, PMID: 26276769), and amplification has been observed in glioblastoma (PMID: 23438035).

III. Representative Data
1.Sanger of PDGFRA V658A-V561A/BaF3 Figure 1. PDGFRA V658A-V561A/BaF3 V658A Figure 2. PDGFRA V658A-V561A/BaF3 V561A
2. Anti-proliferation assay Figure 3. CTG Proliferation Assay of BaF3 PDGFRA V658A Cells (C3).