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药靶细胞株 > kinase激酶细胞株 > CBP73289BCR-ABL1 Q252H/BaF3

BCR-ABL1 Q252H/BaF3
名称 BCR-ABL1 Q252H/BaF3
型号 CBP73289
报价
特点 BCR-ABL1 [Q252H]/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO;
  • 详细内容


CBP73289
I. Introduction

Cell Line Name:

BCR-ABL1 [Q252H]/BaF3

Gene Synonyms:

BCR, ABL1

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, plays a role in regulation of cell growth through ERK5, Rac/JNK, and Stat1/3 pathways (PMID: 10373409). Fusion proteins of BCR-ABL1 resulting in constitutive kinase activity have been reported in various cancers (PMID: 18851712, PMID: 30125955) and a number of Abl1 mutations in the context of BCR-ABL1 have been demonstrated to confer drug resistance (PMID: 24456693).

III. Representative Data

1.WB of  BCR-ABL1 [Q252H]/BaF3

CBP73289-1.jpg


2. Sanger of  BCR-ABL1 [Q252H]/BaF3

CBP73289 sanger1.png

Figure 2. BCR-ABL1 [Q252H]/BaF3 Fusion


CBP73289 sanger2.png

Figure 3. BCR-ABL1 [Q252H]/BaF3 Q252H


3. Anti-proliferation assay

CBP73289 fig.png

Figure 4. CTG Proliferation Assay of BaF3 BCR-ABL1 Q252H Cells (C1).



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